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Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan
Joint Authors
Kobayashi, Yoichi
Furukawa, Seishi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To identify the involvement of leanness and impaired insulin secretion with Japanese gestational diabetes mellitus (GDM).
Method.
A cross-sectional study was conducted comprising 219 at-risk pregnant women who underwent a 75g glucose tolerance test at a single institute in Tokyo, Japan.
We identified GDM and normal glucose tolerance (NGT).
The cut-off value of the homeostasis model assessment insulin resistance (HOMA-IR) for detecting GDM was determined.
The GDM group was divided into subgroups according to insulin resistance based on the cut-off value of HOMA-IR.
We compared the prepregnancy body mass index (BMI) and homeostasis model assessment of β-cell function (HOMA-β) between the group comprising low insulin resistance (LIR) and the group comprising high insulin resistance (HIR).
Results.
Seventy GDM cases and 149 NGT cases were identified.
By using receiver operating characteristic curve analysis, the HOMA-IR cut-off value was determined to be 1.41.
Twenty-five GDM cases (36%) were classified as LIR and forty-five GDM cases (64%) were classified as HIR.
The background including indications for having 75gOGTT and the gestational age having 75gOGTT did not differ between groups.
The BMI of the LIR group was significantly lower than that of the HIR group (20.9±2.8 vs.
24.4 ± 5.5, p<0.01), and the HOMA-β of the LIR group was significantly lower than that of the HIR group (95.5±30.3 vs.
146.0±70.1, p<0.01).
A positive linear correlation was found between BMI and HOMA-β in cases of GDM (r=0.27, p=0.02).
Conclusion.
Leanness with impaired insulin secretion is deeply involved in Japanese gestational diabetes mellitus.
American Psychological Association (APA)
Furukawa, Seishi& Kobayashi, Yoichi. 2019. Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan. Journal of Pregnancy،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1186659
Modern Language Association (MLA)
Furukawa, Seishi& Kobayashi, Yoichi. Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan. Journal of Pregnancy No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1186659
American Medical Association (AMA)
Furukawa, Seishi& Kobayashi, Yoichi. Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan. Journal of Pregnancy. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1186659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186659