Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study
Joint Authors
Angkurawaranon, Chaisiri
Rijken, Marcus
Bierhoff, Marieke
Myat Min, Aung
Gilder, Mary Ellen
Win Tun, Nay
Keereevijitt, Arunrot
Kyi Win, Aye
Win, Elsi
Carrara, Verena Ilona
Brummaier, Tobias
Chu, Cindy S.
Thielemans, Laurence
Sriprawat, Kanlaya
Hanboonkunupakarn, Borimas
Nosten, François
Vugt, Michele van
McGready, Rose
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
Hepatitis B virus (HBV) was believed to have minimal impact on pregnancy outcomes apart from the risk of perinatal transmission.
In more recent years, there have been reports of adverse associations, most consistently preterm birth (PTB), but this is in the context of high rates of caesarean section.
The aim of this study was to explore the association of HBV on pregnancy outcomes in marginalized, low-income populations on the Myanmar-Thailand border.
Methods.
HBsAg positive (+) point of care rapid detection tests results were confirmed by immunoassays.
Women with a confirmed HBsAg status, HIV- and syphilis-negative at first antenatal care screening, singleton fetus and known pregnancy outcome (Aug-2012 to Dec-2016) were included.
Logistic regression analysis was used to evaluate associations between HBV group (controls HBsAg negative, HBsAg+/HBeAg-, or HBsAg+/HBeAg+) and pregnancy outcome and comorbidity.
Results.
Most women were tested, 15,046/15,114 (99.6%) for HBV.
The inclusion criteria were not met for 4,089/15,046 (27.2%) women due mainly to unavailability of pregnancy outcome and nonconfirmation of HBsAg+.
In evaluable women 687/11,025 (6.2%) were HBsAg+, with 476/11,025 (4.3%) HBsAg+/HBeAg- and 211/11,025 (1.9%) were HBsAg+/HBeAg+.
The caesarean section rate was low at 522/8,963 (5.8%).
No significant associations were observed between pregnancy comorbidities or adverse pregnancy outcomes and HBV status.
Conclusions.
The results highlight the disease burden of HBV in women on the Myanmar-Thailand border and support original reports of a lack of significant associations with HBsAg+ irrespective of HBeAg status, for comorbidity, and pregnancy outcomes in deliveries supervised by skilled birth attendants.
American Psychological Association (APA)
Bierhoff, Marieke& Angkurawaranon, Chaisiri& Myat Min, Aung& Gilder, Mary Ellen& Win Tun, Nay& Keereevijitt, Arunrot…[et al.]. 2019. Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study. Journal of Pregnancy،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1186674
Modern Language Association (MLA)
Bierhoff, Marieke…[et al.]. Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study. Journal of Pregnancy No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1186674
American Medical Association (AMA)
Bierhoff, Marieke& Angkurawaranon, Chaisiri& Myat Min, Aung& Gilder, Mary Ellen& Win Tun, Nay& Keereevijitt, Arunrot…[et al.]. Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study. Journal of Pregnancy. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1186674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186674