Phytochemical Screening and In Vivo Antimalarial Activity of Two Traditionally Used Medicinal Plants of Afar Region, Ethiopia, against Plasmodium berghei in Swiss Albino Mice
Joint Authors
Shumbahri, Mohammed
Gebrehiwot, Sibhatu
Eyado, Amelework
Yohannes, Tilahun
Source
Journal of Parasitology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of the present study was to investigate phytochemical components, antiplasmodial activity (in vivo) and evaluate the toxicity of two local medicinal plants, namely, Salvadora persica L.
and Balanites rotundifolia (Van Tiegh.) used in Afar ethnomedicine for the treatment of malaria.
In this study, phytochemical screening has been done using standard methods and the existence of antiplasmodial compounds was detected in these plant extracts.
Four-day Peter’s test was used to determine parasite inhibition, PCV was determined by Wintrob’s method, and effects against loss of body weight and improvements on survival time were determined.
LD50s of the crude extracts have been also done.
Acute toxicity studies of the extracts were carried out in Swiss albino mice prior to antimalarial activity test.
All extracts revealed no obvious acute toxicities on mice up to the highest (5000mg/kg) dose given.
The crude extract was estimated to have oral median lethal dose higher than 5,000 mg/kg.
With the 4-day suppressive test, both plant extracts demonstrated dose-dependent significant reduction in parasitemia level at all test doses compared to the negative control: in the extract of B.
rotundifolia 500 mg/kg extract (60.59±3.25%), 350 mg/kg extract (48.1±1.4), and 200 mg/kg extract (41.33±1.1%) were found.
And in case of S.
Persica 500 mg/kg extract (50.6±4.01%), 350 mg/kg extract (35.85±0.89), and 200 mg/kg extract (27.69±1.14%) were found.
The results of this study provide support for the traditional therapeutic value and the reported antimalarial activity.
American Psychological Association (APA)
Gebrehiwot, Sibhatu& Shumbahri, Mohammed& Eyado, Amelework& Yohannes, Tilahun. 2019. Phytochemical Screening and In Vivo Antimalarial Activity of Two Traditionally Used Medicinal Plants of Afar Region, Ethiopia, against Plasmodium berghei in Swiss Albino Mice. Journal of Parasitology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1186808
Modern Language Association (MLA)
Gebrehiwot, Sibhatu…[et al.]. Phytochemical Screening and In Vivo Antimalarial Activity of Two Traditionally Used Medicinal Plants of Afar Region, Ethiopia, against Plasmodium berghei in Swiss Albino Mice. Journal of Parasitology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1186808
American Medical Association (AMA)
Gebrehiwot, Sibhatu& Shumbahri, Mohammed& Eyado, Amelework& Yohannes, Tilahun. Phytochemical Screening and In Vivo Antimalarial Activity of Two Traditionally Used Medicinal Plants of Afar Region, Ethiopia, against Plasmodium berghei in Swiss Albino Mice. Journal of Parasitology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1186808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186808