Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections
Joint Authors
Acosta, Patricio L.
Byrne, Alana B.
Hijano, Diego R.
Talarico, Laura B.
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-08
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Type I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections.
Upon infection, the IFN-I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells but also modulate the adaptive immune system.
While IFN-I and many IFN stimulated genes are well-known for their protective antiviral role, recent studies have associated them with potential pathogenic functions.
In this review, we summarize the current knowledge regarding the complex effects of human IFN-I responses in respiratory as well as reemerging flavivirus infections of public health significance and the molecular mechanisms by which viral proteins antagonize the establishment of an antiviral host defense.
Antiviral effects and immune modulation of IFN-stimulated genes is discussed in resisting and controlling pathogens.
Understanding the mechanisms of these processes will be crucial in determining how viral replication can be effectively controlled and in developing safe and effective vaccines and novel therapeutic strategies.
American Psychological Association (APA)
Acosta, Patricio L.& Byrne, Alana B.& Hijano, Diego R.& Talarico, Laura B.. 2020. Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1186883
Modern Language Association (MLA)
Acosta, Patricio L.…[et al.]. Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections. Journal of Immunology Research No. 2020 (2020), pp.1-27.
https://search.emarefa.net/detail/BIM-1186883
American Medical Association (AMA)
Acosta, Patricio L.& Byrne, Alana B.& Hijano, Diego R.& Talarico, Laura B.. Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1186883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186883