Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors
Joint Authors
Gao, Yue-Qiu
Zhang, Xin
Gao, Ya-Ting
Ji, Long-Shan
Yu, Zhuo
Huang, Ling-Ying
Fang, Miao
Li, Man
Zhou, Zheng-Hua
Sun, Xue-Hua
Zhu, Xiao-Jun
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Helping B cells and antibody responses is a major function of CD4+T helper cells.
Follicular helper T (Tfh) cells are identified as a subset of CD4+T helper cells, which is specialized in helping B cells in the germinal center reaction.
Tfh cells express high levels of CXCR5, PD-1, IL-21, and other characteristic markers.
Accumulating evidence has demonstrated that the dysregulation of Tfh cells is involved in infectious, inflammatory, and autoimmune diseases, including lymphocytic choriomeningitis virus (LCMV) infection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgG4-related disease (IgG4-RD), Sjögren syndrome (SS), and type 1 diabetes (T1D).
Activation of subset-specific transcription factors is the essential step for Tfh cell differentiation.
The differentiation of Tfh cells is regulated by a complicated network of transcription factors, including positive factors (Bcl6, ATF-3, Batf, IRF4, c-Maf, and so on) and negative factors (Blimp-1, STAT5, IRF8, Bach2, and so on).
The current knowledge underlying the molecular mechanisms of Tfh cell differentiation at the transcriptional level is summarized in this paper, which will provide many perspectives to explore the pathogenesis and treatment of the relevant immune diseases.
American Psychological Association (APA)
Ji, Long-Shan& Sun, Xue-Hua& Zhang, Xin& Zhou, Zheng-Hua& Yu, Zhuo& Zhu, Xiao-Jun…[et al.]. 2020. Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1186941
Modern Language Association (MLA)
Ji, Long-Shan…[et al.]. Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1186941
American Medical Association (AMA)
Ji, Long-Shan& Sun, Xue-Hua& Zhang, Xin& Zhou, Zheng-Hua& Yu, Zhuo& Zhu, Xiao-Jun…[et al.]. Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1186941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186941