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Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy
Joint Authors
Noh, Ji-Yoon
Yoon, Suk Ran
Kim, Tae-Don
Choi, Inpyo
Jung, Haiyoung
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Innate immunity represents the first barrier for host defense against microbial infection.
Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses.
They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules.
TLRs are expressed either on the cell surface or within endosomes of innate immune cells.
NK cells are one of the innate immune cells and also express TLRs to recognize or respond to PAMPs.
TLRs in NK cells induce the innate immune responses against bacterial and viral infections via inducing NK cytotoxicity and cytokine production.
In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy.
American Psychological Association (APA)
Noh, Ji-Yoon& Yoon, Suk Ran& Kim, Tae-Don& Choi, Inpyo& Jung, Haiyoung. 2020. Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1186966
Modern Language Association (MLA)
Noh, Ji-Yoon…[et al.]. Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1186966
American Medical Association (AMA)
Noh, Ji-Yoon& Yoon, Suk Ran& Kim, Tae-Don& Choi, Inpyo& Jung, Haiyoung. Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1186966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186966