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Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection
Joint Authors
Ullah, Nadeem
Hao, Ling
Wu, Yaqi
Zhang, Yandi
Lei, Qing
Banga Ndzouboukou, Jo-Lewis
Lin, Xiaosong
Fan, Xionglin
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tuberculosis (TB) remains a major and global problem of public health.
An effective TB subunit vaccine is urgently needed.
Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control the target pathogen.
In this study, we compared the immunogenicity and protective efficacy of CMFO subunit vaccines against primary progressive TB in two different adjuvant systems: the MTO oil-in-water (O/W) emulsion composed of monophosphoryl lipid A (MPL), trehalose-6,60-dibehenate (TDB), and oil in water emulsion MF59 and the DMT liposome containing dimethyldioctadecylammonium bromide (DDA), monophosphoryl lipid A (MPL), and trehalose-6,60-dibehenate (TDB).
Our results demonstrated that the DMT-adjuvanted CMFO could confer more significant protection against M.
tuberculosis infection than the CMFO/MTO did in mice.
In particular, the adjuvant DMT showed a stronger ability than the O/W emulsion to adjuvant CMFO subunit vaccine and enhanced protection, attributed to elicit Th1-biased responses, strong Th1/Th17 cytokine responses, and IFN-γ+ or IL-2+ T cell responses.
Therefore, our findings demonstrate that the liposome delivery system shows more effectiveness to adjuvant TB subunit vaccine than O/W emulsion and highlight the importance of adjuvant formulation for the better efficacy of a protein vaccine.
American Psychological Association (APA)
Ullah, Nadeem& Hao, Ling& Wu, Yaqi& Zhang, Yandi& Lei, Qing& Banga Ndzouboukou, Jo-Lewis…[et al.]. 2020. Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186974
Modern Language Association (MLA)
Ullah, Nadeem…[et al.]. Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1186974
American Medical Association (AMA)
Ullah, Nadeem& Hao, Ling& Wu, Yaqi& Zhang, Yandi& Lei, Qing& Banga Ndzouboukou, Jo-Lewis…[et al.]. Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186974