Infiltration of Immunoinflammatory Cells and Related ChemokineInterleukin Expression in Different Gastric Immune Microenvironments
Joint Authors
Yuan, Yuan
Lv, Zhi
Wang, Ang
Nie, Siru
Wen, Jing
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Gastric mucosal immune microenvironment plays an important role in the occurrence and development of diseases such as inflammation and cancer.
In the present study, single-sample gene set enrichment analysis (ssGSEA) was used to evaluate the expression of cytokines and the degree of immune cell infiltration in four different gastric mucosa tissues from normal gastric mucosa, simple gastritis, and atrophic gastritis to gastric cancer.
Here, we show the immune microenvironments of these four gastric mucosae were significantly different.
From inflammation to gastric cancer, most immunoinflammatory cells showed a downward trend such as central memory CD4 T cell.
Instead, several cells showed an upward trend such as macrophage.
Additionally, we found some chemokines/interleukins were illustrated to be low expressed (or highly expressed) in precancerous stage and highly expressed (or low expressed) in postcancerous stage, which demonstrated an opposite expression characteristic in pre-/postcancerous stage.
American Psychological Association (APA)
Wang, Ang& Nie, Siru& Lv, Zhi& Wen, Jing& Yuan, Yuan. 2020. Infiltration of Immunoinflammatory Cells and Related ChemokineInterleukin Expression in Different Gastric Immune Microenvironments. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187012
Modern Language Association (MLA)
Wang, Ang…[et al.]. Infiltration of Immunoinflammatory Cells and Related ChemokineInterleukin Expression in Different Gastric Immune Microenvironments. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187012
American Medical Association (AMA)
Wang, Ang& Nie, Siru& Lv, Zhi& Wen, Jing& Yuan, Yuan. Infiltration of Immunoinflammatory Cells and Related ChemokineInterleukin Expression in Different Gastric Immune Microenvironments. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187012