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Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy
Joint Authors
Yang, Xiaomei
Liu, Aiqun
Zhou, Huihui
Yin, Shihua
Zhu, Lichen
Zhong, Dani
Xie, Shenxia
Li, Yangzi
Hou, Xiaoqiong
HuaYao, Xiaoqiong
Zhao, Minlong
Ding, Ziqiang
Zhao, Xinyue
Mo, Fengzhen
Lu, Xiaoling
Shi, Wei
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited.
With the exception of the commercialized CD19 CAR-T for hematological malignancies and other CAR-T therapies aiming mostly at extracellular antigens achieving great success, the rareness and scarcity of TCR-like CAR-T therapies might be due to their current status and limitations.
This review provides the probable optimized initiatives for improving TCR-like CAR-T reprogramming and discusses single-domain antibodies administered as an alternative to conventional scFvs and secreted by CAR-T cells, which might be of great value to the development of CAR-T immunotherapies for intracellular antigens.
American Psychological Association (APA)
Zhu, Lichen& Yang, Xiaomei& Zhong, Dani& Xie, Shenxia& Shi, Wei& Li, Yangzi…[et al.]. 2020. Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187015
Modern Language Association (MLA)
Zhu, Lichen…[et al.]. Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187015
American Medical Association (AMA)
Zhu, Lichen& Yang, Xiaomei& Zhong, Dani& Xie, Shenxia& Shi, Wei& Li, Yangzi…[et al.]. Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187015