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sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings
Joint Authors
Du, Xiaochen
Chen, Yan
Zhu, Jie
Bai, Zhenjiang
Hua, Jun
Li, Ying
Zhang, Guangbo
Lv, Hai-tao
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis.
We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis.
Methods.
182 children were allocated into four groups as follows: control group (CG, 90), simple appendicitis (SA, 12), purulent appendicitis (PA, 49), and gangrenous appendicitis (GA, 31).
Prior to appendectomy, blood was collected and sent for analysis of routine examination and cytokines (sB7H3 and TNF-α).
We compared values of all measured parameters according to histological findings.
Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group.
The diagnostic effects of significant markers were assessed by ROC curves.
Results.
Only the levels of CRP, FIB, and sB7H3 had a remarkable rising trend in AA-based groups, while differences in the levels of CRP and FIB between simple appendicitis and purulent appendicitis were not statistically significant.
In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix.
Furthermore, sB7H3 had a high diagnostic value in predicting AA and complex appendicitis (PA+GA) in children.
However, the diagnostic performance of sB7H3 for distinguishing PA from GA was not remarkable.
Additionally, only the levels of CRP and sB7H3 were statistically different between the nonperforated appendicitis group and the perforated appendicitis group.
The diagnostic performance of CRP and sB7H3 could not merely predict perforation of AA in children; however, the diagnostic performance was improved after combination.
Conclusions.
sB7H3 could be used as a valuable marker to predict the presence of AA and complex AA in children.
However, the diagnostic value of sB7H3 to predict gangrenous/perforated appendicitis was not found to be remarkable.
The combination of sB7H3 and CRP might improve the prediction of perforated appendicitis.
American Psychological Association (APA)
Du, Xiaochen& Chen, Yan& Zhu, Jie& Bai, Zhenjiang& Hua, Jun& Li, Ying…[et al.]. 2020. sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187060
Modern Language Association (MLA)
Du, Xiaochen…[et al.]. sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187060
American Medical Association (AMA)
Du, Xiaochen& Chen, Yan& Zhu, Jie& Bai, Zhenjiang& Hua, Jun& Li, Ying…[et al.]. sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187060