PCSK9: A Potential Therapeutic Target for Sepsis
Joint Authors
Sun, Shanshan
Yuan, Yuan
Zhang, Yi
Chen, Zhi
Wu, Wei
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often upregulated in the presence of sepsis and infectious diseases.
In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol (LDL) receptors (LDL-R) of the hepatocytes and the very low-density lipoprotein cholesterol receptors (VLDL-R) of the adipocytes, which then subsequently reduced pathogenic lipid uptake and clearance/sequestration.
Moreover, it might improve cholesterol accumulation and augment toll-like receptor function in macrophages, which supported inflammatory responses.
Accordingly, PCSK9 might show detrimental effects on immune host response and survival in sepsis.
However, the exact roles of PCSK9 in the pathogenesis of sepsis are still not well defined.
In this review, we summarized the literatures focusing on the roles of PCSK9 in sepsis.
Our review provided an additional insight in the role of PCSK9 in sepsis, which might serve as a potential target for the treatment of sepsis.
American Psychological Association (APA)
Yuan, Yuan& Wu, Wei& Sun, Shanshan& Zhang, Yi& Chen, Zhi. 2020. PCSK9: A Potential Therapeutic Target for Sepsis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187062
Modern Language Association (MLA)
Yuan, Yuan…[et al.]. PCSK9: A Potential Therapeutic Target for Sepsis. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187062
American Medical Association (AMA)
Yuan, Yuan& Wu, Wei& Sun, Shanshan& Zhang, Yi& Chen, Zhi. PCSK9: A Potential Therapeutic Target for Sepsis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187062