Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway
Joint Authors
Fan, Li
Qiu, Dongbo
Huang, Guo
Chen, Jingrou
Wu, Qiongli
Xiong, Shiqiu
Wu, Changyou
Peng, Yanwen
Zhang, Qi
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Wogonin (5,7-dihydroxy-8-methoxyflavone) is an ingredient of the extracts from Scutellaria baicalensis, which has documented a wide spectrum of anti-inflammatory and antitumor activities, including inhibiting regulatory T cells, regulating effector T cell functions, and mediating macrophage immunity.
However, the potential effect of Wogonin on B cells has not been fully understood.
Here, our results showed that Wogonin inhibited IL-10 secretion in B cells.
When purified B cells were activated by lipopolysaccharide (LPS) in vitro, the amount of IL-10 production in supernatant was decreased by Wogonin significantly.
The protective role of B cells on dextran sulfate sodium- (DSS-) induced colitis was alleviated after exposure to Wogonin.
Furthermore, administration of Wogonin on LPS-treated B cells suppressed phosphorylation of STAT3 and ERK, but not AKT.
Interestingly, among those IL-10 signaling-associated transcription factors, mRNA and protein levels of Hif-1α were specifically decreased by Wogonin.
Overall, our study indicates that Wogonin suppresses potentially IL-10 production in B cells via inhibition of the STAT3 and ERK signaling pathway as well as inhibition of mRNA and protein levels of the transcription factor Hif-1α.
These results provide novel and potential molecular targets of Wogonin in B cells and help us further understand its mechanism of action, which could potentially improve its clinical application in the future.
American Psychological Association (APA)
Fan, Li& Qiu, Dongbo& Huang, Guo& Chen, Jingrou& Wu, Qiongli& Xiong, Shiqiu…[et al.]. 2020. Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187106
Modern Language Association (MLA)
Fan, Li…[et al.]. Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway. Journal of Immunology Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187106
American Medical Association (AMA)
Fan, Li& Qiu, Dongbo& Huang, Guo& Chen, Jingrou& Wu, Qiongli& Xiong, Shiqiu…[et al.]. Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187106