The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets
Joint Authors
Xie, Xu-biao
Wang, Peng
Zhang, Qian
Tan, Liang
Xu, Yanan
Zhao, Yong
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
T cells are an important part of the adaptive immune system and play critical roles in the elimination of various pathogens.
T cells could differentiate into distinct cellular subsets under different extracellular signals and then play different roles in maintaining host homeostasis and defense.
The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family.
The mTOR signaling pathway is closely involved in a variety of cell biological processes, including cell growth and cell metabolism, by senses and integrates various environmental cues.
Recent studies showed that mTOR including mTORC1 and mTORC2 is closely involved in the development of T cell subpopulations such as Th1, Th2, Th9, Th17, follicular helper T cells (Tfh), and Treg cells through distinctive pathways.
We herein mainly focused on the recent progress in understanding the roles of mTOR in regulating the development and differentiation of CD4+ T cell subsets.
American Psychological Association (APA)
Wang, Peng& Zhang, Qian& Tan, Liang& Xu, Yanan& Xie, Xu-biao& Zhao, Yong. 2020. The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187130
Modern Language Association (MLA)
Wang, Peng…[et al.]. The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets. Journal of Immunology Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1187130
American Medical Association (AMA)
Wang, Peng& Zhang, Qian& Tan, Liang& Xu, Yanan& Xie, Xu-biao& Zhao, Yong. The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187130