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Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China
Joint Authors
Tian, Xin-Ping
Wang, Li
Zheng, Wenjie
Zhang, Fengchun
Zhang, Zhaocui
Liu, Suying
Guo, Ling
Wu, Qingjun
Hou, Yong
Zeng, Xiaofeng
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate clinical features, independent associated factors, treatment, and outcome of patients with peripheral neuropathy (PN) in eosinophilic granulomatosis with polyangiitis (EGPA).
Methods.
We retrospectively analyzed clinical data of 110 EGPA patients from 2007 to 2019 in Peking Union Medical College Hospital.
The independent factors associated with PN in EGPA were analyzed with univariate and multivariate logistic regressions.
Results.
In EGPA with PN, paresthesia and muscle weakness were observed in 82% and 33% of patients, respectively.
Both the upper and lower limbs were involved in 51% of patients.
30% of EGPA patients had symmetrical multiple peripheral neuropathy, whereas only 16.4% presented with mononeuritis multiplex.
Compared to patients without PN, patients with PN had a higher erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, Birmingham vasculitis activity score (BVAS), and positivity of myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA).
Regarding manifestations, patients with PN tended to develop weight loss and arthritis or joint pain.
Notably, ANCA positivity, arthritis or joint pain, and higher BVAS were found to be independent associated factors for PN in EGPA.
Patients with PN more frequently need glucocorticoid pulses and intravenous infusion of cyclophosphamide.
With the longest follow-up of 11.0 years, we found that age and cardiac involvement were risk factors for survival, and female was the protective factor.
Conclusion.
PN in EGPA frequently displays with symmetrical multiple peripheral neuropathy in China.
Positive ANCA, arthritis or joint pain, and higher BVAS are the independent associated factors of PN in EGPA.
Glucocorticoids with immunosuppressants are vital therapeutic strategy.
American Psychological Association (APA)
Zhang, Zhaocui& Liu, Suying& Guo, Ling& Wang, Li& Wu, Qingjun& Zheng, Wenjie…[et al.]. 2020. Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187135
Modern Language Association (MLA)
Zhang, Zhaocui…[et al.]. Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1187135
American Medical Association (AMA)
Zhang, Zhaocui& Liu, Suying& Guo, Ling& Wang, Li& Wu, Qingjun& Zheng, Wenjie…[et al.]. Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187135