![](/images/graphics-bg.png)
Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine
Joint Authors
Granados, Julio
Fragoso, Alberto
Pedraza-Jiménez, Mérida
Espinoza-González, Laura
Ceja-Mendoza, María Luisa
Sánchez-Mercado, Hugo
Robles-Pérez, Gloria
Medina-Rivero, Emilio
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A complex mixture of peptides plays a key role in the regulation of the immune system; different sources as raw materials mainly from animals and vegetables have been reported to provide these extracts.
The batch-to-batch product consistency depends on in-process controls established.
However, when an immunomodulator is a customized product obtained from the same volunteer who will receive the product to personalize the treatment, the criteria to establish the consistency between volunteers are different.
In this sense, it is expected to have the same molecular weight range although the profile of peptide abundance is different.
Here, we characterized the peptide profile of three extracts of an immunomodulator obtained from the urine of different volunteers suffering from three different diseases (i.e., allergic rhinitis, rheumatoid arthritis, and chronic rhinopharyngitis), using size exclusion chromatography (SEC) and mass spectrometry (MS).
The peptides contained in the immunomodulators were stable after six months, stored in a refrigerator.
Our results showed a chromatographic profile with the same range of low molecular weight (less than 17 kDa) in all analyzed samples by SEC; these results were also confirmed by MS showing an exact mass spectrum from 3 to 13 kDa.
The fact that the peptide profiles were conserved during a six-month period at refrigeration conditions (2 to 8°C) maintaining the quality and stability of the immunomodulator supports the notion that it might be an alternative in the treatment of chronic hypersensibility disorders.
American Psychological Association (APA)
Fragoso, Alberto& Pedraza-Jiménez, Mérida& Espinoza-González, Laura& Ceja-Mendoza, María Luisa& Sánchez-Mercado, Hugo& Robles-Pérez, Gloria…[et al.]. 2020. Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187143
Modern Language Association (MLA)
Fragoso, Alberto…[et al.]. Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1187143
American Medical Association (AMA)
Fragoso, Alberto& Pedraza-Jiménez, Mérida& Espinoza-González, Laura& Ceja-Mendoza, María Luisa& Sánchez-Mercado, Hugo& Robles-Pérez, Gloria…[et al.]. Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187143