Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse
Joint Authors
Surcel, Mihaela
Marcu, Radu Dragos
Mischianu, Dan Liviu Dorel
Iorga, Lucian
Diaconu, Camelia Cristina
Munteanu, Adriana Narcisa
Isvoranu, Gheorghita
Bratu, Ovidiu Gabriel
Constantin, Carolina
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pelvic organ prolapse is a frequent health problem in women, encountered worldwide, its physiopathology being still incompletely understood.
The integrity of the pelvic-supportive structures is a key element that prevents the prolapse of the pelvic organs.
Numerous researchers have underlined the role of connective tissue molecular changes in the pathogenesis of pelvic organ prolapse and have raised the attention upon oxidative stress as an important element involved in its appearance.
The advancements made over the years in terms of molecular biology have allowed researchers to investigate how the constituent elements of the pelvic-supportive structures react in conditions of oxidative stress.
The purpose of this paper is to underline the importance of oxidative stress in the pathogenesis of pelvic organ prolapse, as well as to highlight the main oxidative stress molecular changes that appear at the level of the pelvic-supportive structures.
Sustained mechanical stress is proven to be a key factor in the appearance of pelvic organ prolapse, correlating with increased levels of free radicals production and mitochondrial-induced fibroblasts apoptosis, the rate of cellular apoptosis depending on the intensity of the mechanical stress, and the period of time the mechanical stress is applied.
Oxidative stress hinders normal cellular signaling pathways, as well as different important cellular components like proteins, lipids, and cellular DNA, therefore significantly interfering with the process of collagen and elastin synthesis.
American Psychological Association (APA)
Marcu, Radu Dragos& Mischianu, Dan Liviu Dorel& Iorga, Lucian& Diaconu, Camelia Cristina& Surcel, Mihaela& Munteanu, Adriana Narcisa…[et al.]. 2020. Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187151
Modern Language Association (MLA)
Marcu, Radu Dragos…[et al.]. Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187151
American Medical Association (AMA)
Marcu, Radu Dragos& Mischianu, Dan Liviu Dorel& Iorga, Lucian& Diaconu, Camelia Cristina& Surcel, Mihaela& Munteanu, Adriana Narcisa…[et al.]. Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187151