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Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis
Joint Authors
Zhong, Jixin
Duan, Lihua
Wei, Yingying
Shang, Ke
Peng, Linan
Li, Yi
Zhang, Na
Chen, Jie
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation.
However, the role of CCN3 in rheumatoid arthritis (RA), a classic autoimmune and inflammatory disease, remains elusive.
RA is a chronic systemic autoimmune disease that eventually leads to cartilage and bone destruction and joint dysfunction.
In this study, we investigated the potential of serum CCN3 as a biomarker for RA.
The serum levels of CCN3 were measured by ELISA.
The clinical and laboratory parameters were collected from a clinical record system, and disease activity was determined by joint disease activity score 28 (DAS28).
Our results showed that the serum levels of CCN3 were significantly increased in RA patients compared to healthy controls.
Furthermore, the CCN3 level was positively correlated with DAS28 (CRP), DAS28 (ESR), and the level of anti-CCP Ab, an autoantibody highly specific for RA.
Furthermore, CCN3 showed a positive correlation with inflammatory cytokine IL-6, while no significant correlation with TNF-α was observed.
These data suggest that CCN3 plays an important role in the development of RA and might be a potential disease activity biomarker for RA.
American Psychological Association (APA)
Wei, Yingying& Peng, Linan& Li, Yi& Zhang, Na& Shang, Ke& Duan, Lihua…[et al.]. 2020. Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187157
Modern Language Association (MLA)
Wei, Yingying…[et al.]. Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1187157
American Medical Association (AMA)
Wei, Yingying& Peng, Linan& Li, Yi& Zhang, Na& Shang, Ke& Duan, Lihua…[et al.]. Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187157