miR-24-3pKLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT
Joint Authors
Jing, Pengyu
Xie, Nianlin
Zhao, Nan
Zhu, Ximing
Li, Pei
Gao, Guizhou
Dang, Haizhou
Gu, Zhongping
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Reprogramming of the tumor immune microenvironment is a salient feature during metastasis in LUAD.
miR-24-3p and KLF8, which are key regulators of the tumor immune microenvironment, had been proved to show metastasis-promoting property in LUAD.
However, whether miR-24-3p could regulate LUAD metastasis by targeting KLF8 remains unclear.
This study explored the functions and mechanisms of miR-24-3p/KLF8 signaling in advanced LUAD.
The expression level of miR-24-3p and KLF8 were tested in LUAD patients, and the corelation of miR-24-3p and KLF8 was evaluated.
The interaction of miR-24-3p and KLF8 was demonstrated by luciferase reporter activity assay, in vitro migration and invasion studies, and in vivo metastatic studies.
miR-24-3p level was downregulated in LUAD and negatively associated with KLF8 mRNA expression.
miR-24-3p controls LUAD metastasis by directly targeting KLF8 and inducing Snail and E-cadherin expressions.
Targeting the miR-24-3p/KLF8/EMT axis might be of great therapeutic value to advanced LUAD patients.
American Psychological Association (APA)
Jing, Pengyu& Xie, Nianlin& Zhao, Nan& Zhu, Ximing& Li, Pei& Gao, Guizhou…[et al.]. 2020. miR-24-3pKLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187173
Modern Language Association (MLA)
Jing, Pengyu…[et al.]. miR-24-3pKLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187173
American Medical Association (AMA)
Jing, Pengyu& Xie, Nianlin& Zhao, Nan& Zhu, Ximing& Li, Pei& Gao, Guizhou…[et al.]. miR-24-3pKLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187173