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ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-- Mouse through Promoting M2 Macrophage Polarization
Joint Authors
Zhu, Junfeng
You, Yong
Zhang, Xiaoqing
Wang, Xiao
Yue, Dan
Meng, Fanxiang
Wang, Yuanyuan
Sun, Xun
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study was to identify functions of ILC2, a newly found innate lymphoid cell which mainly locates in mucosa organs like lungs and intestines, in IBD.
We injected rIL-33 protein to C57/BL6 mouse to explore how IL-33 induces ILC2 proliferation.
The results showed that ILC2 reached a proliferation peak at day 5 and expressed multiple surface markers like CD127, C-kit, CD69, CD44, ST2, CD27, DR3, MHCII, and CD90.2.
ILC2 also expressed high quantity of IL-13 and IL-5 and few IL-17A which indicates a potentially immunological function in IBD development.
Afterwards, we transferred sort purified ILC2 to Rag1-/- mouse given DSS to induce acute colitis in order to explore the innate function of ILC2.
Data showed that ILC2 alleviates DSS-induced acute innate colitis by repairing epithelial barrier and restore body weight.
Furthermore, we found that ILC2 can cause macrophages polarizing to M2 macrophages in the gut.
Therefore, we concluded that ILC2 played a therapeutic role in mouse acute colitis.
American Psychological Association (APA)
You, Yong& Zhang, Xiaoqing& Wang, Xiao& Yue, Dan& Meng, Fanxiang& Zhu, Junfeng…[et al.]. 2020. ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-- Mouse through Promoting M2 Macrophage Polarization. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187261
Modern Language Association (MLA)
You, Yong…[et al.]. ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-- Mouse through Promoting M2 Macrophage Polarization. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187261
American Medical Association (AMA)
You, Yong& Zhang, Xiaoqing& Wang, Xiao& Yue, Dan& Meng, Fanxiang& Zhu, Junfeng…[et al.]. ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-- Mouse through Promoting M2 Macrophage Polarization. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187261