![](/images/graphics-bg.png)
Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro
Joint Authors
Xie, Nianlin
Tian, Feng
Lei, Jie
Ni, Yunfeng
Si, Shaokui
Jiang, Tao
Lu, Qiang
Yang, Guang
Zhong, Daixing
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study, the effects of single immunoglobin IL-1 receptor-related protein (SIGIRR) on tumor necrosis factor- (TNF-) receptor-associated factor 6 (TRAF6) ubiquitination in acute lung injury (ALI) were evaluated in both alveolar epithelial cells and alveolar macrophage cells in vitro.
Our results found that SIGIRR negatively regulated TRAF6 ubiquitination and such SIGIRR inhibition could enhance the TRAF6 expression in both alveolar epithelial cells (AECs) and alveolar macrophage cells (AMCs).
SIGIRR knockdown may increase NF-κB activity via TRAF6 regulation by the classical but not the nonclassical NF-κB signaling pathway.
Such modulation between TRAF6 and SIGIRR could affect cytokine secretion and exacerbate the immune response; the IL-8, NFKB1, and NFKBIA mRNA levels were reduced after SIGIRR overexpression.
The current study reveals the molecular mechanisms of the negative regulatory roles of SIGIRR on the innate immune response related to the LPS/TLR-4 signaling pathway and provides evidence for strategies to clinically treat inflammatory diseases.
American Psychological Association (APA)
Tian, Feng& Lu, Qiang& Lei, Jie& Ni, Yunfeng& Xie, Nianlin& Zhong, Daixing…[et al.]. 2020. Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187271
Modern Language Association (MLA)
Tian, Feng…[et al.]. Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187271
American Medical Association (AMA)
Tian, Feng& Lu, Qiang& Lei, Jie& Ni, Yunfeng& Xie, Nianlin& Zhong, Daixing…[et al.]. Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187271