FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation
Joint Authors
Zurac, Sabina
Popp, Cristiana
Nichita, Luciana
Turcu, Gabriela
Cioplea, Mirela
Georgescu, Daniela
Sticlaru, Liana
Cioroianu, Alexandra
Nedelcu, Roxana
Rauta, Alin
Mogodici, Cristian
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment.
We present a retrospective cohort study including 52 cases of melanoma with regression.
There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma.
FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells.
FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor clones and of regulatory T cells could eliminate the ability of tumor cells to escape the immune defense of the host.
American Psychological Association (APA)
Cioplea, Mirela& Nichita, Luciana& Georgescu, Daniela& Sticlaru, Liana& Cioroianu, Alexandra& Nedelcu, Roxana…[et al.]. 2020. FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187299
Modern Language Association (MLA)
Cioplea, Mirela…[et al.]. FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187299
American Medical Association (AMA)
Cioplea, Mirela& Nichita, Luciana& Georgescu, Daniela& Sticlaru, Liana& Cioroianu, Alexandra& Nedelcu, Roxana…[et al.]. FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187299