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The Scribble Complex PDZ Proteins in Immune Cell Polarities
Joint Authors
Chacon-Salinas, Rommel
Santos-Mendoza, Teresa
Cabello-Gutiérrez, Carlos
Barreda, Dante
Gutiérrez-González, Luis H.
Martínez-Cordero, Erasmo
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
hScrib and hDlg belong to the PDZ family of proteins.
Since the identification of these highly phylogenetically conserved scaffolds, an increasing amount of experiments has elucidated the roles of hScrib and hDlg in a variety of cell functions.
Remarkably, their participation during the establishment of polarity in epithelial cells is well documented.
Although the role of both proteins in the immune system is scantly known, it has become a growing field of investigation.
Here, we summarize the interactions and functions of hScrib and hDlg1, which participate in diverse functions involving cell polarization in immune cells, and discuss their relevance in the immune cell biology.
The fundamental role of hScrib and hDlg1 during the establishment of the immunological synapse, hence T cell activation, and the recently described role of hScrib in reactive oxygen species production in macrophages and of hDlg1 in cytokine production by dendritic cells highlight the importance of both proteins in immune cell biology.
The expression of these proteins in other leukocytes can be anticipated and needs to be confirmed.
Due to their multiple interaction domains, there is a wide range of possible interactions of hScrib and hDlg1 that remains to be explored in the immune system.
American Psychological Association (APA)
Barreda, Dante& Gutiérrez-González, Luis H.& Martínez-Cordero, Erasmo& Cabello-Gutiérrez, Carlos& Chacon-Salinas, Rommel& Santos-Mendoza, Teresa. 2020. The Scribble Complex PDZ Proteins in Immune Cell Polarities. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187308
Modern Language Association (MLA)
Barreda, Dante…[et al.]. The Scribble Complex PDZ Proteins in Immune Cell Polarities. Journal of Immunology Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187308
American Medical Association (AMA)
Barreda, Dante& Gutiérrez-González, Luis H.& Martínez-Cordero, Erasmo& Cabello-Gutiérrez, Carlos& Chacon-Salinas, Rommel& Santos-Mendoza, Teresa. The Scribble Complex PDZ Proteins in Immune Cell Polarities. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187308