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The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma
Joint Authors
Căruntu, Constantin
Nicolae, Ilinca
Popa, Gabriela Loredana
Tampa, Mircea
Mitran, Madalina
Mitran, Cristina
Matei, Clara
Georgescu, Simona-Roxana
Dumitru, Adrian
Manolescu, Loredana
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis.
Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development.
Beta HPV types are components of the normal flora; however, under the influence of certain cofactors, the virus may trigger a malignant process.
Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis.
In addition, the oncoproteins E6 and E7 of beta HPV types differ biochemically from their counterparts in the structure of alpha HPV types, resulting in different mechanisms of action in carcinogenesis.
The aim of our manuscript is to present an updated point of view on the involvement of beta HPV types in cSCC pathogenesis.
American Psychological Association (APA)
Tampa, Mircea& Mitran, Cristina& Mitran, Madalina& Nicolae, Ilinca& Dumitru, Adrian& Matei, Clara…[et al.]. 2020. The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187317
Modern Language Association (MLA)
Tampa, Mircea…[et al.]. The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1187317
American Medical Association (AMA)
Tampa, Mircea& Mitran, Cristina& Mitran, Madalina& Nicolae, Ilinca& Dumitru, Adrian& Matei, Clara…[et al.]. The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187317