A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters
Joint Authors
Lee, Su Yeon
Shin, Soo-Yong
Yoon, Young Jo
Park, Yu Rang
Source
Journal of Healthcare Engineering
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
MicroRNA (miRNA) binding is primarily based on sequence, but structure-specific binding is also possible.
Various prediction algorithms have been developed for predicting miRNA target genes; the results, however, have relatively high levels of false positives, and the degree of overlap between predicted targets from different methods is poor or null.
We devised a new method for identifying significant miRNA target genes from an extensive list of predicted miRNA target gene relationships using hypergeometric distributions.
We evaluated our method in statistical and semantic aspects using a common miRNA cluster from six solid tumors.
Our method provides statistically and semantically significant miRNA target genes.
Complementing target prediction algorithms with our proposed method may have a significant synergistic effect in finding and evaluating functional annotation and enrichment analysis for miRNA.
American Psychological Association (APA)
Lee, Su Yeon& Shin, Soo-Yong& Yoon, Young Jo& Park, Yu Rang. 2018. A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters. Journal of Healthcare Engineering،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1187324
Modern Language Association (MLA)
Lee, Su Yeon…[et al.]. A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters. Journal of Healthcare Engineering No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1187324
American Medical Association (AMA)
Lee, Su Yeon& Shin, Soo-Yong& Yoon, Young Jo& Park, Yu Rang. A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters. Journal of Healthcare Engineering. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1187324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187324