BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations
Joint Authors
Netea, Mihai G.
van Crevel, Reinout
Mourits, Vera P.
Koeken, Valerie A. C. M.
de Bree, L. Charlotte J.
Moorlag, Simone J. C. F. M.
Chu, Wern Cui
Xu, Xiaoli
Dijkstra, Helga
Lemmers, Heidi
Joosten, Leo A. B.
Wang, Yue
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
BCG vaccination protects not only against tuberculosis but also against heterologous infections.
This effect differs between individuals, yet the factors responsible for this variation are unknown.
BCG-induced nonspecific protection is, at least partially, mediated by innate immune reprogramming (trained immunity), which can be induced by the muramyl dipeptide (MDP) component of peptidoglycans.
We aimed to study whether differential release of MDP in healthy individuals may explain variability of their response to BCG vaccination.
Circulating MDP concentrations were increased up to three months after BCG vaccination.
MDP concentrations at baseline, but not their increase postvaccination, positively correlated with the induction of trained immunity and not with mycobacteria-induced T-cell responses.
Interestingly, MDP concentrations correlated with inflammatory markers in the circulation.
In conclusion, circulating MDP concentrations are associated with the strength of trained immunity responses and thus influence the biological effects of BCG vaccination.
This study increases our understanding about the role of MDP in BCG-induced trained immunity, which might help to optimize vaccine efficacy and explore novel applications of BCG vaccination.
American Psychological Association (APA)
Mourits, Vera P.& Koeken, Valerie A. C. M.& de Bree, L. Charlotte J.& Moorlag, Simone J. C. F. M.& Chu, Wern Cui& Xu, Xiaoli…[et al.]. 2020. BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187325
Modern Language Association (MLA)
Mourits, Vera P.…[et al.]. BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187325
American Medical Association (AMA)
Mourits, Vera P.& Koeken, Valerie A. C. M.& de Bree, L. Charlotte J.& Moorlag, Simone J. C. F. M.& Chu, Wern Cui& Xu, Xiaoli…[et al.]. BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187325