Th1Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure
Joint Authors
Yang, Jinfeng
Lu, Xuan
Pan, Qiaoling
Cao, Hongcui
Li, Lanjuan
Jiang, Bin
Guo, Yurong
Wu, Jian
Huang, Fen
Lv, Feifei
Wei, Daqiao
Shang, Anquan
Yu, Jiong
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
The involvement of cellular immunity in the development of hepatitis E virus (HEV) infection is rare.
We aimed to study the roles of viral load and Th cell responses in acute hepatitis E (AHE) and HEV-related acute liver failure (HEV-ALF).
Methods.
We evaluated viral load and Th1/Th2 cytokine levels in 34 patients with HEV infection, including 17 each with AHE or HEV-ALF.
Seventeen healthy controls (HCs) were also included who were negative for anti-HEV IgM and IgG.
Results.
There was no significant difference in viral load and HEV RNA in the AHE and HEV-ALF groups (both P>0.05).
The Th lymphocyte levels (CD3+, CD4+) in the AHE and HEV-ALF groups were significantly higher than those in the HC group (both P<0.05), but there was no significant difference between the AHE and HEV-ALF groups (P>0.05).
Both IFN-γ and IL-10 showed gradual upward trend from the HC group to the AHE (both P<0.01), but IFN-γ showed a sharp downward trend from the AHE group to the HEV-ALF group (P<0.01) and IL-4 showed gradual upward trend from the AHE group to the HEV-ALF group (P<0.01).There was no significant difference in Th1 and Th2 cytokines between the HEV RNA(+) group and HEV RNA(-) group (all P>0.05).
Th2 bias was observed from the AHE (ratio=58.65) to HEV-ALF (ratio=1.20) groups.
The level of IFN-γ was associated with the outcome of HEV-ALF patients.
Conclusions.
HEV viral load was not associated with aggravation of AHE, and the HEV-ALF patients showed significant Th2 bias, which may be involved in the aggravation of AHE.
American Psychological Association (APA)
Wu, Jian& Guo, Yurong& Lu, Xuan& Huang, Fen& Lv, Feifei& Wei, Daqiao…[et al.]. 2020. Th1Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187349
Modern Language Association (MLA)
Wu, Jian…[et al.]. Th1Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187349
American Medical Association (AMA)
Wu, Jian& Guo, Yurong& Lu, Xuan& Huang, Fen& Lv, Feifei& Wei, Daqiao…[et al.]. Th1Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187349