The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy
Joint Authors
Feng, Qi
Liu, Dongwei
Lu, Yanfang
Liu, Zhangsuo
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide.
The underlying mechanisms of DN are complex and required to be further investigated.
Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN.
Except for traditional functions, abnormally regulated RAS has been proved to be involved in the inflammatory process of DN.
Toll-like receptor 4 (TLR4) is the most deeply studied pattern recognition receptor in the innate immune system, and its activation has been reported to mediate the development of DN.
In this review, we aim at discussing how dysregulated RAS affects TLR4 activation in the kidney that contributes to the exploration of the pathogenesis of DN.
Understanding the interplay of RAS and TLR4 in inducing the progression of DN may provide new insights to develop effective treatments.
American Psychological Association (APA)
Feng, Qi& Liu, Dongwei& Lu, Yanfang& Liu, Zhangsuo. 2020. The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187356
Modern Language Association (MLA)
Feng, Qi…[et al.]. The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187356
American Medical Association (AMA)
Feng, Qi& Liu, Dongwei& Lu, Yanfang& Liu, Zhangsuo. The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187356