The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression
Joint Authors
Zheng, Yayun
Ma, Xue
Su, Dongmei
Zhang, Yue
Yu, Lin
Jiang, Fangfei
Zhou, Xue
Feng, Ying
Ma, Fang
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The function of natural killer (NK) cells, defending against virus infection and tumour progression, is regulated by multiple activating and inhibiting receptors expressed on NK cells, among which sialic acid-bind immunoglobulin-like lectins (Siglecs) act as a vital inhibitory group.
Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands.
Siglec7 and Siglec9 are very similar in distribution, gene encoding, protein sequences, ligand affinity, and functions in regulating the immune system against virus and cancers, but differences still exist between them.
In this review, we aim to discuss the similarities and differences between Siglec7 and Siglec9 and analyze their functions in virus infection and tumour progression in order to develop better anti-viral and anti-tumor immunotherapy in the future.
American Psychological Association (APA)
Zheng, Yayun& Ma, Xue& Su, Dongmei& Zhang, Yue& Yu, Lin& Jiang, Fangfei…[et al.]. 2020. The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187359
Modern Language Association (MLA)
Zheng, Yayun…[et al.]. The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187359
American Medical Association (AMA)
Zheng, Yayun& Ma, Xue& Su, Dongmei& Zhang, Yue& Yu, Lin& Jiang, Fangfei…[et al.]. The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187359