Anti-HMGCR Specificity of HALIP: A Confirmatory Study

Abstract EN

A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies.

It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern).

In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP.

Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver).

A characteristic HALIP was observed.

Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns.

This study confirms that the HALIP is due to human anti-HMGCR antibodies.