The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic Rhinitis

Abstract EN

Objectives.

Interleukin-27 (IL-27) has been reported to inhibit type 2 T helper cell (Th2) response in allergic rhinitis (AR).

However, its effects on group II innate lymphoid cells (ILC2) in AR are not fully understood.

Methods.

Nineteen patients with AR and nineteen controls were enrolled in this study.

The effects of IL-27 on ILC2 differentiation and function as well as the regulation of the IL-27 receptor (IL-27R) were analyzed by tritiated thymidine incorporation, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (PCR), respectively.

AR mice were used to confirm the role of IL-27 in vivo.

Results.

The serum IL-27 protein expression in AR patients was significantly lower compared with controls.

IL-27 decreased the ILC2 proliferation and type II cytokine secretion through the interaction with IL-27R.

IL-27 also inhibited systemic and nasal ILC2 response of AR mice.

Conclusion.

IL-27 inhibited the proliferation and function of ILC2 in AR, implying that IL-27 may be used as new treatment target in AR.