The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic Rhinitis
Joint Authors
Luo, Xi
Zeng, Qingxiang
Li, Yan
Tang, Yiquan
Liu, Wenlong
Luo, Renzhong
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Interleukin-27 (IL-27) has been reported to inhibit type 2 T helper cell (Th2) response in allergic rhinitis (AR).
However, its effects on group II innate lymphoid cells (ILC2) in AR are not fully understood.
Methods.
Nineteen patients with AR and nineteen controls were enrolled in this study.
The effects of IL-27 on ILC2 differentiation and function as well as the regulation of the IL-27 receptor (IL-27R) were analyzed by tritiated thymidine incorporation, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (PCR), respectively.
AR mice were used to confirm the role of IL-27 in vivo.
Results.
The serum IL-27 protein expression in AR patients was significantly lower compared with controls.
IL-27 decreased the ILC2 proliferation and type II cytokine secretion through the interaction with IL-27R.
IL-27 also inhibited systemic and nasal ILC2 response of AR mice.
Conclusion.
IL-27 inhibited the proliferation and function of ILC2 in AR, implying that IL-27 may be used as new treatment target in AR.
American Psychological Association (APA)
Luo, Xi& Zeng, Qingxiang& Li, Yan& Tang, Yiquan& Liu, Wenlong& Luo, Renzhong. 2020. The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic Rhinitis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187389
Modern Language Association (MLA)
Luo, Xi…[et al.]. The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic Rhinitis. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187389
American Medical Association (AMA)
Luo, Xi& Zeng, Qingxiang& Li, Yan& Tang, Yiquan& Liu, Wenlong& Luo, Renzhong. The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic Rhinitis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187389