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Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17Treg Balance
Joint Authors
Chen, Fei-long
Tang, Qingfa
Liang, Xiao
Liu, Chang-Shun
Xia, Ting
Tan, Xiao-Mei
Ren, Mengyue
Wei, Xiao-Han
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mahuang Fuzi Xixin Decoction (MFXD), a Chinese traditional herbal formulation, has been used to treat allergic rhinitis (AR) in China for centuries.
However, the mechanism underlying its effect on AR is unclear.
This study investigated the mechanism underlying the therapeutic effects of MFXD on AR.
Ovalbumin-induced AR rat models were established, which were then treated with MFXD for 14 days.
Symptom scores of AR were calculated.
The structure of the gut microbiota was analyzed by 16S rRNA gene sequencing and qPCR.
Short-chain fatty acid (SCFA) content in rat stool and serum was determined by GC-MS.
Inflammatory and immunological responses were assessed by histopathology, ELISA, flow cytometry, and western blotting.
Our study demonstrated that MFXD reduced the symptom scores of AR and serum IgE and histamine levels.
MFXD treatment restored the diversity of the gut microbiota: it increased the abundance of Firmicutes and Bacteroidetes and decreased the abundance of Proteobacteria and Cyanobacteria.
MFXD treatment also increased SCFA content, including that of acetate, propionate, and butyrate.
Additionally, MFXD administration downregulated the number of Th17 cells and the levels of the Th17-related cytokines IL-17 and RORγt.
By contrast, there was an increase in the number of Treg cells and the levels of the Treg-related cytokines IL-10 and Foxp3.
MFXD and butyrate increased the levels of ZO-1 in the colon.
This study indicated MFXD exerts therapeutic effects against AR, possibly by regulating the gut microbial composition and Th17/Treg balance.
American Psychological Association (APA)
Liang, Xiao& Liu, Chang-Shun& Wei, Xiao-Han& Xia, Ting& Chen, Fei-long& Tang, Qingfa…[et al.]. 2020. Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17Treg Balance. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187404
Modern Language Association (MLA)
Liang, Xiao…[et al.]. Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17Treg Balance. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187404
American Medical Association (AMA)
Liang, Xiao& Liu, Chang-Shun& Wei, Xiao-Han& Xia, Ting& Chen, Fei-long& Tang, Qingfa…[et al.]. Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17Treg Balance. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187404