The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
Joint Authors
Kremláček, J.
Borska, Lenka
Palicka, Vladimir
Borsky, Pavel
Fiala, Zdenek
Hamakova, Kvetoslava
Rehacek, Vit
Malkova, Andrea
Holmannova, Drahomira
Andrys, Ctirad
Svadlakova, Tereza
Krejsek, Jan
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS).
Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases.
The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids.
The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated.
Methods.
Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA).
Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine.
Results and Conclusions.
The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8.
The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls.
It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.
American Psychological Association (APA)
Holmannova, Drahomira& Borska, Lenka& Andrys, Ctirad& Borsky, Pavel& Kremláček, J.& Hamakova, Kvetoslava…[et al.]. 2020. The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187445
Modern Language Association (MLA)
Holmannova, Drahomira…[et al.]. The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187445
American Medical Association (AMA)
Holmannova, Drahomira& Borska, Lenka& Andrys, Ctirad& Borsky, Pavel& Kremláček, J.& Hamakova, Kvetoslava…[et al.]. The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187445