Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia
Joint Authors
Xiao, Hao
Wang, Huiping
Zhou, Mei
Dong, Yi
Wang, Zhitao
Tao, Qianshan
Zhai, Zhimin
Zhang, Qing
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14+HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology.
However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their multiple roles in solid tumors.
Methods.
We examined the frequencies of M-MDSCs identified for CD14+HLA-DRlow/- by flow cytometry in the peripheral circulating blood of 109 newly diagnosed adult patients with AML and 30 healthy controls (HC).
Then, we, respectively, validated the clinic significance of circulating M-MDSCs on the relevance of spectral features for diagnostic stratification, induction therapy response, treatment effect maintenance, and long-term survival in AML.
Results.
Circulating M-MDSC frequencies of AML were significantly higher than those of HC both in CD14+ monocytes (46.22%±2.95% vs.
1.07%±0.17%, p<0.01) and peripheral blood mononuclear cells (PBMCs) (4.21%±0.80% vs.
0.17%±0.03%, p<0.01).
Elevated circulating M-MDSCs in patients with AML were significantly associated with low complete remission (CR) rate, high relapse/refractory rate, and poor long-term survival, but had no correlation with common clinic risks and cytogenetic molecular risk categories.
Conclusions.
It was demonstrated that circulating M-MDSCs are elevated and associated with poor prognosis in AML, suggesting M-MDSCs might be a prognostic indicator for AML.
American Psychological Association (APA)
Wang, Huiping& Tao, Qianshan& Wang, Zhitao& Zhang, Qing& Xiao, Hao& Zhou, Mei…[et al.]. 2020. Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187449
Modern Language Association (MLA)
Wang, Huiping…[et al.]. Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187449
American Medical Association (AMA)
Wang, Huiping& Tao, Qianshan& Wang, Zhitao& Zhang, Qing& Xiao, Hao& Zhou, Mei…[et al.]. Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187449