Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis

Joint Authors

Zhao, Zhihong
Zhou, Jingbin
He, Chen
Gao, Feng
Guo, Yu
Qu, Feng
Liu, Yujie

Source

Journal of Immunology Research

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-07-28

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Biology

Abstract EN

Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis.

Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages.

However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition.

Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages.

We also compared the gene expression profiles of macrophages in healthy people and OA patients and found the characteristic changes of special macrophages in the OA knee.

We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.

American Psychological Association (APA)

Zhou, Jingbin& Zhao, Zhihong& He, Chen& Gao, Feng& Guo, Yu& Qu, Feng…[et al.]. 2020. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187515

Modern Language Association (MLA)

Zhou, Jingbin…[et al.]. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1187515

American Medical Association (AMA)

Zhou, Jingbin& Zhao, Zhihong& He, Chen& Gao, Feng& Guo, Yu& Qu, Feng…[et al.]. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187515

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1187515