Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis
Joint Authors
Zhao, Zhihong
Zhou, Jingbin
He, Chen
Gao, Feng
Guo, Yu
Qu, Feng
Liu, Yujie
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis.
Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages.
However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition.
Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages.
We also compared the gene expression profiles of macrophages in healthy people and OA patients and found the characteristic changes of special macrophages in the OA knee.
We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.
American Psychological Association (APA)
Zhou, Jingbin& Zhao, Zhihong& He, Chen& Gao, Feng& Guo, Yu& Qu, Feng…[et al.]. 2020. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187515
Modern Language Association (MLA)
Zhou, Jingbin…[et al.]. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1187515
American Medical Association (AMA)
Zhou, Jingbin& Zhao, Zhihong& He, Chen& Gao, Feng& Guo, Yu& Qu, Feng…[et al.]. Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187515