Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?
Joint Authors
Herrera, María Teresa
Juárez, Esmeralda
Torres, Martha
Carreto-Binaghi, Laura E.
Alejandre, Alejandro
Martínez-Orozco, José Arturo
Becerril-Vargas, Eduardo
Gonzalez, Yolanda
Guzmán-Beltrán, Silvia
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide.
Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response.
In children, malnutrition and immaturity of the immune system contribute to an inadequate immune response.
Coinfections, though rarely described in TB, might be associated with host immune deficiencies.
Here, we describe the immunological evaluation of eight pediatric patients infected with a member of the M.
tuberculosis complex, most of them with concomitant pulmonary infections (bacteria, viruses, or fungi).
We assessed the functionality of several innate immunity receptors, IL-12 receptor, and IFN-γ receptor, as well as the antioxidant levels (glutathione), which are essential mechanisms for fighting intracellular pathogens such as M.
tuberculosis.
This study is aimed at developing a thorough immunological evaluation of patients with TB and a coinfection.
American Psychological Association (APA)
Carreto-Binaghi, Laura E.& Juárez, Esmeralda& Guzmán-Beltrán, Silvia& Herrera, María Teresa& Torres, Martha& Alejandre, Alejandro…[et al.]. 2020. Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187540
Modern Language Association (MLA)
Carreto-Binaghi, Laura E.…[et al.]. Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187540
American Medical Association (AMA)
Carreto-Binaghi, Laura E.& Juárez, Esmeralda& Guzmán-Beltrán, Silvia& Herrera, María Teresa& Torres, Martha& Alejandre, Alejandro…[et al.]. Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187540