TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer
Joint Authors
Yin, Huanhuan
Li, Ruili
Sun, Xiangling
Feng, Cuihua
Tan, Yujie
Guo, Wei
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
We investigated the efficacy of TILs and anti-PD1 combination therapy in patients with metastatic cervical cancer with low MSI expression and PDL1-negative.
Methods.
A total of 80 patients were put on TILs and anti-PD1 combination therapy, and the progression-free survival time (PFS) and overall survival time (OS) were assessed by Kaplan–Meier analysis.
Univariate and multivariate analyses were performed to identify factors that could predict the prognosis of metastatic cervical cancer in the previously described patients.
Results.
The objective response rate was 25%, whereas the mPFS and mOS were 6.1 and 11.3 months, respectively.
The therapeutic efficacy was influenced by the characteristics of TILs, infection with HPV, and development of fever just after the therapy.
Conclusion.
Overall, our results show that the combination therapy of TILs and anti-PD1 significantly improves the prognosis of metastatic cervical cancer.
American Psychological Association (APA)
Yin, Huanhuan& Guo, Wei& Sun, Xiangling& Li, Ruili& Feng, Cuihua& Tan, Yujie. 2020. TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187573
Modern Language Association (MLA)
Yin, Huanhuan…[et al.]. TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187573
American Medical Association (AMA)
Yin, Huanhuan& Guo, Wei& Sun, Xiangling& Li, Ruili& Feng, Cuihua& Tan, Yujie. TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187573
