Global Distribution of Common Variable Immunodeficiency (CVID) in the Light of the UNDP Human Development Index (HDI): A Preliminary Perspective of a Rare Disease
Joint Authors
Weifenbach, Niels
Schneckenburger, Annalena A. C.
Lötters, Stefan
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Common variable immunodeficiency (CVID), although the most common primary immunodeficiency in humans, is a rare disease.
We explored the spatial global distribution and country-wise prevalence of CVID, based on published data and those available from databases.
As a country’s medical progress is linked to its technological and socio-economic developmental status, we expected that observed CVID prevalence was linked to human wellbeing.
To assess this, we examined the correlation of observed CVID prevalence and the UNDP Human Development Index (HDI), which is a key measure of human development.
Seventy-four data sets from 47 countries were available (most of them no older than 10 years).
Analyses revealed that observed CVID prevalence ranged from 0.001 to 3.374 per 100,000 (mean 0.676±0.83) and was highest in “high” HDI countries (Spearman’s rho=0.757).
Observed prevalence was particularly high in countries where immunodeficiencies are systematically documented in registers.
In “low” and “middle” HDI countries, CVID awareness is extremely poor.
Assuming that true CVID prevalence does not differ among countries, this study, though preliminary, provides evidence that the discrepancy between observed and (unknown) true prevalence can be clearly linked to the countries’ developmental status.
As a potential alternative explanation, we briefly discuss the possibility that variation in CVID prevalence is related to human genetic lineage.
American Psychological Association (APA)
Weifenbach, Niels& Schneckenburger, Annalena A. C.& Lötters, Stefan. 2020. Global Distribution of Common Variable Immunodeficiency (CVID) in the Light of the UNDP Human Development Index (HDI): A Preliminary Perspective of a Rare Disease. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187582
Modern Language Association (MLA)
Weifenbach, Niels…[et al.]. Global Distribution of Common Variable Immunodeficiency (CVID) in the Light of the UNDP Human Development Index (HDI): A Preliminary Perspective of a Rare Disease. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187582
American Medical Association (AMA)
Weifenbach, Niels& Schneckenburger, Annalena A. C.& Lötters, Stefan. Global Distribution of Common Variable Immunodeficiency (CVID) in the Light of the UNDP Human Development Index (HDI): A Preliminary Perspective of a Rare Disease. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187582