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Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell
Joint Authors
Chen, Zhi-Yi
Yang, Chaopin
Li, Yue
Yang, Yaozhang
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
NK cells are lymphocytes with antitumor properties and can directly lyse tumor cells in a non-MHC-restricted manner.
However, the tumor microenvironment affects the immune function of NK cells, which leads to immune evasion.
This may be related to the pathogenesis of some diseases.
Therefore, great efforts have been made to improve the immunotherapy effect of natural killer cells.
NK cells from different sources can meet different clinical needs, in order to minimize the inhibition of NK cells and maximize the response potential of NK cells, for example, modification of NK cells can increase the number of NK cells in tumor target area, change the direction of NK cells, and improve their targeting ability to malignant cells.
Checkpoint blocking is also a promising strategy for NK cells to kill tumor cells.
Combination therapy is another strategy for improving antitumor ability, especially in combination with oncolytic viruses and nanomaterials.
In this paper, the mechanisms affecting the activity of NK cells were reviewed, and the therapeutic potential of different basic NK cell strategies in tumor therapy was focused on.
The main strategies for improving the immune function of NK cells were described, and some new strategies were proposed.
American Psychological Association (APA)
Yang, Chaopin& Li, Yue& Yang, Yaozhang& Chen, Zhi-Yi. 2020. Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187586
Modern Language Association (MLA)
Yang, Chaopin…[et al.]. Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell. Journal of Immunology Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1187586
American Medical Association (AMA)
Yang, Chaopin& Li, Yue& Yang, Yaozhang& Chen, Zhi-Yi. Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1187586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187586