Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes
Joint Authors
Łaczmański, Łukasz
Karpiński, Paweł
Sąsiadek, Maria M.
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Current immunotherapies are effective only in a subset of patients, likely due to several factors including defects in tumor cell antigen presentation, decreased response to immune effectors, and molecular heterogeneity of cancers.
Recent molecular classifications enable the categorization of many tumor types.
However, deregulation of major histocompatibility complex (MHC) gene expression is poorly characterized in the context of molecular cancer subtypes.
To suppress the confounding effect of immune infiltrates on expression patterns of immunoregulators, we identified and removed genes with strong correlation to estimated immune compartment levels in each tumor type.
Next, we reanalyzed a total of 13 TCGA cancer types encompassing 5651 tumors and 485 normal adjacent tissues by performing unsupervised clustering of 14 MHC genes.
Subsequently, resultant clusters were statistically compared in terms of expression of other immune-related genes.
Three MHC expression clusters were discovered by unsupervised clustering.
We identified concordantly decreased expression of MHC genes (MHC-low) in 26 out of 55 molecular subtypes.
Consequently, our study underlines the urgent need for designing strategies to enhance tumor MHC expression that could improve immune cold tumor rejection by cytotoxic T lymphocytes.
American Psychological Association (APA)
Karpiński, Paweł& Łaczmański, Łukasz& Sąsiadek, Maria M.. 2020. Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187597
Modern Language Association (MLA)
Karpiński, Paweł…[et al.]. Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187597
American Medical Association (AMA)
Karpiński, Paweł& Łaczmański, Łukasz& Sąsiadek, Maria M.. Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187597