The Function and Role of the Th17Treg Cell Balance in Inflammatory Bowel Disease
Joint Authors
Yan, Jun-bin
Luo, Min-min
Chen, Zhi-yun
He, Bei-hui
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder.
The pathogenesis of IBD is not yet clear.
Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4+ T cells, contributes to IBD.
Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD.
Therefore, Th17/Treg cell balance is crucial.
Some regulatory factors affecting the production and maintenance of these cells are also important for the proper regulation of the Th17/Treg balance; these factors include T cell receptor (TCR) signaling, costimulatory signals, cytokine signaling, bile acid metabolites, and the intestinal microbiota.
This article focuses on our understanding of the function and role of the balance between Th17/Treg cells in IBD and these regulatory factors and their clinical significance in IBD.
American Psychological Association (APA)
Yan, Jun-bin& Luo, Min-min& Chen, Zhi-yun& He, Bei-hui. 2020. The Function and Role of the Th17Treg Cell Balance in Inflammatory Bowel Disease. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187599
Modern Language Association (MLA)
Yan, Jun-bin…[et al.]. The Function and Role of the Th17Treg Cell Balance in Inflammatory Bowel Disease. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187599
American Medical Association (AMA)
Yan, Jun-bin& Luo, Min-min& Chen, Zhi-yun& He, Bei-hui. The Function and Role of the Th17Treg Cell Balance in Inflammatory Bowel Disease. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187599