The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response
Joint Authors
Fu, Weiwei
Zhao, Shuchao
Fu, Haiyang
Shi, Weiping
Sun, Mengqi
Li, Yujun
Li, Hong
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The sirtuins (SIRTs), including seven family members, belong to class III histone deacetylase (HDAC) enzymes, which have been intensively investigated in cancers.
Although the function of SIRTs in the cancer immunology is explored, SIRT-specific mechanisms regulating necroptosis-related innate immune response are not clear.
In our present study, we found that both the mRNA and protein expression levels of SIRT3 and SIRT6 are significantly increased in the PCa tissues (HR, CI P=3.30E−03; HR, CI P=2.35E−08; and HR, CI P=9.20E−08) and were associated with patients’ Gleason score and nodal metastasis.
Furthermore, multivariate analysis showed that the PCa patients with higher expression levels of SIRT3 and SIRT6 had shorter overall survival (OS).
Mechanistically, we found that SIRT3 and SIRT6 promote prostate cancer progress by inhibiting RIPK3-mediated necroptosis and innate immune response.
Knockdown of both SIRT3 and SIRT6 not only activates TNF-induced necroptosis but also refreshes the corresponding recruitment of macrophages and neutrophils.
Overall, our study identified that SIRT3 and SIRT6 are key regulators of necroptosis during prostate cancer progression.
American Psychological Association (APA)
Fu, Weiwei& Li, Hong& Fu, Haiyang& Zhao, Shuchao& Shi, Weiping& Sun, Mengqi…[et al.]. 2020. The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187604
Modern Language Association (MLA)
Fu, Weiwei…[et al.]. The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. Journal of Immunology Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187604
American Medical Association (AMA)
Fu, Weiwei& Li, Hong& Fu, Haiyang& Zhao, Shuchao& Shi, Weiping& Sun, Mengqi…[et al.]. The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187604