Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs
Joint Authors
Melgaço, Juliana Gil
Brito e Cunha, Danielle
Azamor, Tamiris
da Silva, Andrea Marques Vieira
Tubarão, Luciana Neves
Gonçalves, Rafael Braga
Monteiro, Robson Q.
Missailidis, Sotiris
da Costa Neves, Patricia Cristina
Ano Bom, Ana Paula Dinis
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
The severe acute respiratory syndrome caused by the new coronavirus (SARS-CoV-2), termed COVID-19, has been highlighted as the most important infectious disease of our time, without a vaccine and treatment available until this moment, with a big impact on health systems worldwide, and with high mortality rates associated with respiratory viral disease.
The medical and scientific communities have also been confronted by an urgent need to better understand the mechanism of host-virus interaction aimed at developing therapies and vaccines.
Since this viral disease can trigger a strong innate immune response, causing severe damage to the pulmonary tract, immunotherapies have also been explored as a means to verify the immunomodulatory effect and improve clinical outcomes, whilst the comprehensive COVID-19 immunology still remains under investigation.
In this review, both cellular and molecular immunopathology as well as hemostatic disorders induced by SARS-CoV-2 are summarized.
The immunotherapeutic approaches based on the most recent clinical and nonclinical studies, emphasizing their effects for the treatment of COVID-19, are also addressed.
The information presented elucidates helpful insights aiming at filling the knowledge gaps around promising immunotherapies that attempt to control the dysfunction of host factors during the course of this infectious viral disease.
American Psychological Association (APA)
Melgaço, Juliana Gil& Brito e Cunha, Danielle& Azamor, Tamiris& da Silva, Andrea Marques Vieira& Tubarão, Luciana Neves& Gonçalves, Rafael Braga…[et al.]. 2020. Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1187611
Modern Language Association (MLA)
Melgaço, Juliana Gil…[et al.]. Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs. Journal of Immunology Research No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1187611
American Medical Association (AMA)
Melgaço, Juliana Gil& Brito e Cunha, Danielle& Azamor, Tamiris& da Silva, Andrea Marques Vieira& Tubarão, Luciana Neves& Gonçalves, Rafael Braga…[et al.]. Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1187611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187611