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Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer
Joint Authors
Xie, Rui
Xue, Yingwei
Li, Chunfeng
Fang, Tianyi
Yu, Xuefeng
Wang, Yimin
Yin, Xin
Zhai, Zhao
Zhang, Yu
Yang, Yongheng
You, Qi
Li, Zhiguo
Ma, Yan
Song, Haibin
Shi, Huawen
Zhang, Yongle
Gao, Hongyu
Sun, Yihua
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) are markers of systemic inflammation.
However, there is little evidence of the value of inflammation in the early diagnosis of gastric cancer (GC).
A total of 2,606 patients diagnosed with GC in the past three years and 3,219 healthy controls over the same period were included in this study.
Peripheral blood samples were obtained to analyze the NLR, PLR, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9).
The optimal cutoff levels for the NLR and PLR were defined by receiver operating characteristic (ROC) curve analysis (NLR=2.258, PLR=147.368).
The value of different biomarkers for diagnosing GC was compared by the area under the curve (AUC).
The NLR and PLR showed diagnostic sensitivity in GC (AUC=0.715, AUC=0.707).
Using the Bonferroni correction, the NLR and PLR were superior to CEA and CA19-9 in the diagnosis of GC (P<0.0001).
The systemic inflammatory markers were significantly higher in the early stage of GC than tumor markers.
After grouping patients and healthy controls by gender, we found that the diagnostic significance of combined NLR and PLR for GC was greater in male patients than in female patients (P<0.0001).
The diagnostic value of the NLR and PLR in GC is higher than that of the traditional tumor markers CEA and CA19-9.
Systemic markers of inflammation are more valuable in male than female patients.
American Psychological Association (APA)
Fang, Tianyi& Wang, Yimin& Yin, Xin& Zhai, Zhao& Zhang, Yu& Yang, Yongheng…[et al.]. 2020. Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187658
Modern Language Association (MLA)
Fang, Tianyi…[et al.]. Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer. Journal of Immunology Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187658
American Medical Association (AMA)
Fang, Tianyi& Wang, Yimin& Yin, Xin& Zhai, Zhao& Zhang, Yu& Yang, Yongheng…[et al.]. Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187658