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Elemental Diet Enriched with Amino Acids Alleviates Mucosal Inflammatory Response and Prevents Colonic Epithelial Barrier Dysfunction in Mice with DSS-Induced Chronic Colitis
Joint Authors
Hou, Xiaohua
Guo, Di
Yang, Jun
Ling, Fangmei
Tu, Lei
Li, Junrong
Chen, Yidong
Zou, Kaifang
Zhu, Liangru
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Clinical data suggest that enteral nutrition (EN) effectively decreases disease activity and maintains remission in patients with inflammatory bowel disease (IBD).
However, the modulatory effects of EN on the intestinal mucosal immune system remain unclear.
Aims.
This study first aimed at comparing the therapeutic effects of three EN formulas on ameliorating dextran sulfate sodium- (DSS-) induced chronic colitis; with the most effective formula, we then examined its influence on the mucosal inflammatory response and epithelial barrier function.
Methods.
The effect of EN formulas on colitis in mice was assessed by body weight, disease activity index scores, colon length, and H&E staining for pathological examination.
Colonic and circulating cytokine expression levels and the frequencies of immune cells were also analyzed.
Intestinal epithelial barrier function was evaluated by detecting tight junction proteins.
Results.
We found that among the three EN formulas, an elemental diet (ED) containing enriched amino acids restored the colitis-related reduction in body weight better than the other two EN formulas.
ED amino acids suppressed the release of colonic proinflammatory mediators and maintained the expression of tight junction proteins in these mice.
ED amino acid treatment mitigated the colitis-induced increase in CD103+CD11b+ dendritic cells and CD4+ and CD8+ T cells and inhibited the predominant Th1/Th17 responses particularly in the colonic mucosal lamina propria of mice with colitis.
Conclusions.
We showed that ED amino acids can be an effective immunomodulatory agent to reduce colitis-related inflammation by inhibiting proinflammatory mediators and Th1/Th17 cell responses and by repairing the disrupted epithelial barrier.
American Psychological Association (APA)
Guo, Di& Yang, Jun& Ling, Fangmei& Tu, Lei& Li, Junrong& Chen, Yidong…[et al.]. 2020. Elemental Diet Enriched with Amino Acids Alleviates Mucosal Inflammatory Response and Prevents Colonic Epithelial Barrier Dysfunction in Mice with DSS-Induced Chronic Colitis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187686
Modern Language Association (MLA)
Guo, Di…[et al.]. Elemental Diet Enriched with Amino Acids Alleviates Mucosal Inflammatory Response and Prevents Colonic Epithelial Barrier Dysfunction in Mice with DSS-Induced Chronic Colitis. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187686
American Medical Association (AMA)
Guo, Di& Yang, Jun& Ling, Fangmei& Tu, Lei& Li, Junrong& Chen, Yidong…[et al.]. Elemental Diet Enriched with Amino Acids Alleviates Mucosal Inflammatory Response and Prevents Colonic Epithelial Barrier Dysfunction in Mice with DSS-Induced Chronic Colitis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187686