![](/images/graphics-bg.png)
Upregulation of CD146 in Pediatric B-Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes
Joint Authors
Zahran, Asmaa M.
El-Badawy, Omnia
Elsayh, Khalid I.
Mohamed, Wael M. Y.
Riad, Khalid F.
Abdel-Rahim, Mona H.
Rayan, Amal
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background and Aim.
We studied through flow cytometry the expression of CD146 on different T cells, and B-cell ALL blasts trying to correlate its expression with different prognostic factors of B-cell ALL and treatment outcomes.
Patients and Methods.
All pediatric patients with B-cell ALL were subjected to bone marrow examination and cytochemistry, flow cytometric immunophenotyping using monoclonal antibodies utilized for diagnosis of B-ALL including CD34, CD19, CD10, CD22, and intracellular IgM.
The diagnosis was based on standard morphologic, cytochemical, and immunophenotypic followed by flow cytometric detection of CD146 expression on blast cells, CD4+, and CD8+ T cells.
Results.
Significant accumulations of CD146+CD4+ cells, CD146+CD8+ cells, CD4+, CD8+, and lymphocytes in patients were compared to controls, the mean percentages of CD146+CD4+ cells, CD146+CD8+ cells, and CD146+ blasts were significantly higher in patients than controls, and in addition, these cells were associated with poor overall survival and disease-free survival.
The median OS for patients with complete response was 22±1.633 (95%CI=18.799‐25.201), while for those without complete response, it was 13±3.928 (95%CI=5.301‐25.699), with log‐rank=5.71, P=0.017.
Conclusion.
CD146 was expressed significantly in children’s B-ALL and associated with poor prognostic features including poor response and treatment outcomes and could be a possible poor prognostic factor in pediatric B-cell ALL.
American Psychological Association (APA)
Zahran, Asmaa M.& El-Badawy, Omnia& Elsayh, Khalid I.& Mohamed, Wael M. Y.& Riad, Khalid F.& Abdel-Rahim, Mona H.…[et al.]. 2020. Upregulation of CD146 in Pediatric B-Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187729
Modern Language Association (MLA)
Zahran, Asmaa M.…[et al.]. Upregulation of CD146 in Pediatric B-Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187729
American Medical Association (AMA)
Zahran, Asmaa M.& El-Badawy, Omnia& Elsayh, Khalid I.& Mohamed, Wael M. Y.& Riad, Khalid F.& Abdel-Rahim, Mona H.…[et al.]. Upregulation of CD146 in Pediatric B-Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187729