Microvessel Density in Patients with Cutaneous Melanoma: An Up-to-Date Systematic Review and Meta-Analysis
Joint Authors
Tepetes, Konstantinos
Perivoliotis, Konstantinos
Ntellas, Panagiotis
Dadouli, Katerina
Koutoukoglou, Prodromos
Ioannou, Maria
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Background.
We conducted a meta-analysis, in order to appraise the effect of microvessel density (MVD) on the survival of patients with cutaneous melanoma.
Methods.
This study was conducted according to the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.
A systematic literature search in electronic databases (MEDLINE, Web of Science, and Cochrane Central Register of Controlled Clinical Trials) was performed.
Fixed Effects or Random Effects model was used, based on the Cochran Q test.
Results.
In total 9 studies (903 patients) were included.
Pooled HR for overall survival (OS) and disease-free survival (DFS) were 2.62 (95% CI: 0.71–9.60, p=0.15) and 2.64 (95% CI: 0.82–8.47, p=0.10), respectively.
Odds ratios of overall survival between high and low MVD groups, at 12 (1.45, 95% CI: 0.16–13.24), 36 (2.93, 95% CI: 0.63–13.59), and 60 (4.09, 95% CI: 0.85–19.77) months did not reach statistical significance.
Significant superiority of low MVD group, in terms of DFS, at all time intervals (OR: 4.69, p<0.0001; OR: 2.18, p=0.004; OR: 7.46, p=0.01, resp.) was documented.
Discussion.
MVD does not affect the HR of OS and DFS.
A strong correlation with DFS rates at 12, 36, and 60 months was recorded.
American Psychological Association (APA)
Perivoliotis, Konstantinos& Ntellas, Panagiotis& Dadouli, Katerina& Koutoukoglou, Prodromos& Ioannou, Maria& Tepetes, Konstantinos. 2017. Microvessel Density in Patients with Cutaneous Melanoma: An Up-to-Date Systematic Review and Meta-Analysis. Journal of Skin Cancer،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1187735
Modern Language Association (MLA)
Perivoliotis, Konstantinos…[et al.]. Microvessel Density in Patients with Cutaneous Melanoma: An Up-to-Date Systematic Review and Meta-Analysis. Journal of Skin Cancer No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1187735
American Medical Association (AMA)
Perivoliotis, Konstantinos& Ntellas, Panagiotis& Dadouli, Katerina& Koutoukoglou, Prodromos& Ioannou, Maria& Tepetes, Konstantinos. Microvessel Density in Patients with Cutaneous Melanoma: An Up-to-Date Systematic Review and Meta-Analysis. Journal of Skin Cancer. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1187735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187735