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The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma
Joint Authors
Sunjaya, Angela Felicia
Sunjaya, Anthony Paulo
Tan, Sukmawati Tansil
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year.
The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year.
BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs.
Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin.
This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls.
BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells.
Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells.
The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.
American Psychological Association (APA)
Sunjaya, Anthony Paulo& Sunjaya, Angela Felicia& Tan, Sukmawati Tansil. 2017. The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma. Journal of Skin Cancer،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1187736
Modern Language Association (MLA)
Sunjaya, Anthony Paulo…[et al.]. The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma. Journal of Skin Cancer No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1187736
American Medical Association (AMA)
Sunjaya, Anthony Paulo& Sunjaya, Angela Felicia& Tan, Sukmawati Tansil. The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma. Journal of Skin Cancer. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1187736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187736