Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry
Joint Authors
Koo, Bon-Kwon
Kang, Jeehoon
Han, Jung-Kyu
Kang, Hyun-Jae
Ki, You-Jeong
Yang, Han-Mo
Park, Kyung Woo
Kim, Chee-Hoon
Kim, Hyo-Soo
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
In this study, we sought to compare the efficacy and safety of the Xience Prime/Xience V/Promus EES and Biomatrix/Biomatrix Flex/Nobori BES with resolute integrity/resolute ZES using the grand drug-eluting stent (Grand-DES) registry.
Background.
Currently, new-generation drug-eluting stents (DESs) are used as the standard of care in patients undergoing percutaneous coronary intervention.
No study has simultaneously compared everolimus-eluting stent (EES), biolimus-eluting stent (BES), and zotarolimus-eluting stent (ZES).
Methods.
Stent-related composite outcomes (target lesion failure) and patient-related composite outcomes were compared in crude and propensity score-matched analysis.
Results.
Of the 17,286 patients in the Grand-DES group, 5,137, 2,970, and 4,990 patients in the EES, BES, and ZES groups completed a three-year follow-up.
In the propensity score-matched cohort, the stent-related outcome (EES vs.
BES vs.
ZES; 5.9% vs.
6.7% vs.
7.1%, P=0.226) and patient-related outcomes (12.7% vs.
13.5% vs.
14.3%, P=0.232) were similar among the three groups, at 3 years.
The rate of definite or probable stent thrombosis (0.6% vs.
0.8% vs.
0.5%, P=0.549) was similar.
In the multivariate analysis, chronic kidney disease was the strongest predictor of stent thrombosis (adjusted hazard ratio 3.178; 95% confidence interval 1.621–6.229; P<0.001).
Conclusions.
In this robust real-world registry with unrestricted use of EES, BES, and ZES, the three stent groups showed comparable safety and efficacy at the 3-year follow-up.
American Psychological Association (APA)
Ki, You-Jeong& Park, Kyung Woo& Kang, Jeehoon& Kim, Chee-Hoon& Han, Jung-Kyu& Yang, Han-Mo…[et al.]. 2020. Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187770
Modern Language Association (MLA)
Ki, You-Jeong…[et al.]. Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry. Journal of Interventional Cardiology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187770
American Medical Association (AMA)
Ki, You-Jeong& Park, Kyung Woo& Kang, Jeehoon& Kim, Chee-Hoon& Han, Jung-Kyu& Yang, Han-Mo…[et al.]. Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187770