Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions
Joint Authors
Zelis, Jo M.
Tonino, Pim A. L.
Pijls, Nico H. J.
De Bruyne, Bernard
Kirkeeide, Richard L.
Gould, K. Lance
Johnson, Nils P.
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
With the increasing prevalence of aortic stenosis (AS) due to a growing elderly population, a proper understanding of its physiology is paramount to guide therapy and define severity.
A better understanding of the microvasculature in AS could improve clinical care by predicting left ventricular remodeling or anticipate the interplay between epicardial stenosis and myocardial dysfunction.
In this review, we combine five decades of literature regarding microvascular, coronary, and aortic valve physiology with emerging insights from newly developed invasive tools for quantifying microcirculatory function.
Furthermore, we describe the coupling between microcirculation and epicardial stenosis, which is currently under investigation in several randomized trials enrolling subjects with concomitant AS and coronary disease.
To clarify the physiology explained previously, we present two instructive cases with invasive pressure measurements quantifying coexisting valve and coronary stenoses.
Finally, we pose open clinical and research questions whose answers would further expand our knowledge of microvascular dysfunction in AS.
These trials were registered with NCT03042104, NCT03094143, and NCT02436655.
American Psychological Association (APA)
Zelis, Jo M.& Tonino, Pim A. L.& Pijls, Nico H. J.& De Bruyne, Bernard& Kirkeeide, Richard L.& Gould, K. Lance…[et al.]. 2020. Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187792
Modern Language Association (MLA)
Zelis, Jo M.…[et al.]. Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions. Journal of Interventional Cardiology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187792
American Medical Association (AMA)
Zelis, Jo M.& Tonino, Pim A. L.& Pijls, Nico H. J.& De Bruyne, Bernard& Kirkeeide, Richard L.& Gould, K. Lance…[et al.]. Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187792