The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis
Joint Authors
Xu, Gang
Zhang, Ying
Liu, Yanyan
Li, Qing
Huang, Yimin
Shang, Weifeng
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics.
However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AKI) remains unclear.
Method.
Medline, Embase, ClinicalTrials.gov, Cochrane Library database, and the China National Knowledge Infrastructure (CNKI) were used to identify relevant studies from their inception to November 31, 2019.
Studies that met the inclusion criteria were included.
Relevant data were extracted to obtain pooled sensitivity (SEN) and specificity (SPE), summary receiver operating characteristic curve (ROC), and area under the ROC (AUC or AUROC).
A bivariate mixed-effects regression model was used for data analysis.
Results.
A total of 946 patients from 8 eligible studies were included.
Across all the studies, the diagnostic odds ratio (DOR) for uKIM-1 level to predict CI-AKI was 19 (95% CI 10–39), with SEN and SPE of 0.84 and 0.78, respectively.
The AUROC for uKIM-1 in predicting CI-AKI was 0.88 (95% CI 0.85–0.90).
There was a substantial heterogeneity across the studies (I2 was 37.73% for the summary sensitivity and 69.31% for the summary specificity).
Conclusion.
Urinary KIM-1 has a high predictive value for diagnosis of CI-AKI in patients who have undergone cardiac catheterization.
American Psychological Association (APA)
Li, Qing& Huang, Yimin& Shang, Weifeng& Zhang, Ying& Liu, Yanyan& Xu, Gang. 2020. The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187806
Modern Language Association (MLA)
Li, Qing…[et al.]. The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis. Journal of Interventional Cardiology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187806
American Medical Association (AMA)
Li, Qing& Huang, Yimin& Shang, Weifeng& Zhang, Ying& Liu, Yanyan& Xu, Gang. The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187806